Cyclophosphamide hydrate

CAS No. 6055-19-2

Cyclophosphamide hydrate( Cyclophosphamide monohydrate )

Catalog No. M15264 CAS No. 6055-19-2

A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities; used to treat cancers and autoimmune diseases.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
50MG 30 In Stock
100MG 42 In Stock
200MG 52 In Stock
500MG 78 In Stock
1G 120 In Stock

Biological Information

  • Product Name
    Cyclophosphamide hydrate
  • Note
    Research use only, not for human use.
  • Brief Description
    A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities; used to treat cancers and autoimmune diseases.
  • Description
    A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities; used to treat cancers and autoimmune diseases.Chemotherapeutic Agents Approved(In Vitro):Cyclophosphamide induces outer membrane blebbing, leads to DNA fragmentation, as revealed by TUNEL staining of free 3'-OH DNA ends, and induces cleavage of the caspase 3 and caspase 7 substrate PARP in 9L/P450 cells. Bcl-2 expression fully blocks the activation of both initiator caspases as well as the effector caspase 3 in cells treated with activated Cyclophosphamide. Bcl-2 inhibits the cytotoxic effects but not the cytostatic effects of activated Cyclophosphamide. Cyclophosphamide inhibits the AChE reversibly with an IC50 of 511 μM. Carbon tetrachloride does not affect the direct cytotoxicity of cyclophosphamide or 4-hydroxycyclophosphamide to cells in culture.(In Vivo):Cyclophosphamide (injected i.p.;2mg/mouse in 0.1 mL PBS, in C3H mice bearing SW1 tumors) increases the percentage of cells that stained for CD3, CD4 or CD8 in both spleens and tumors.
  • In Vitro
    Cyclophosphamide induces outer membrane blebbing, leads to DNA fragmentation, as revealed by TUNEL staining of free 3'-OH DNA ends, and induces cleavage of the caspase 3 and caspase 7 substrate PARP in 9L/P450 cells. Bcl-2 expression fully blocks the activation of both initiator caspases as well as the effector caspase 3 in cells treated with activated Cyclophosphamide. Bcl-2 inhibits the cytotoxic effects but not the cytostatic effects of activated Cyclophosphamide.Cyclophosphamide inhibits the AChE reversibly with an IC50 of 511 μM.Carbon tetrachloride does not affect the direct cytotoxicity of cyclophosphamide or 4-hydroxycyclophosphamide to cells in culture.
  • In Vivo
    Cyclophosphamide (injected i.p.;2mg/mouse in 0.1 mL PBS, in C3H mice bearing SW1 tumors) increases the percentage of cells that stained for CD3, CD4 or CD8 in both spleens and tumors. Animal Model:Six to eight-week old female C3H/HeN mice bearing SW1 tumors Dosage:2 mg/mouse Administration:Injected i.p.; 2mg/mouse in 0.1 mL PBS; Four days Result:Increased the percentage of cells that stained for CD3, CD4 or CD8 in both spleens and tumors.
  • Synonyms
    Cyclophosphamide monohydrate
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA Alkylator
  • Recptor
    DNA|MRP1
  • Research Area
    Cancer
  • Indication
    Chemotherapeutic

Chemical Information

  • CAS Number
    6055-19-2
  • Formula Weight
    279.1012
  • Molecular Formula
    C7H17Cl2N2O3P
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 38 mg/mL
  • SMILES
    O.ClCCN(CCCl)P1(=O)NCCCO1
  • Chemical Name
    2H-1,3,2-Oxazaphosphorin-2-amine, N,N-bis(2-chloroethyl)tetrahydro-, 2-oxide, hydrate (1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

molnova catalog
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